Ghetto

"Ghetto" is an ongoing gag where a character calls a place ghetto. The joke debuted in the video "Squidward's House IN REAL LIFE" at the 15 second mark.

Ghetto Meaning
Ghetto has two meanings. The meaning used in the gag is second one. Directly from Wikipedia, the second meaning of ghetto is "The term has deep cultural meaning in the United States, especially in the context of segregation and civil rights; as such, it has been widely used in the country to refer to inner-city neighborhoods that are mainly poor. It is also used in some European countries such as Romania and Slovenia to refer to poor neighborhoods.".

Most Recent Video With The Gag
Since the gag is over 7 years old, there are tons of videos with the gag, but the most recent video with the gag as of August 10th 2021, is "Emobob works at Taco Bell" at the 57 second mark.